Ketamine was approved and first used clinically in 1970. It has been the time-tested drug in different clinical situations over last five decades. Its first published use was in pediatric ophthalmological procedures as an analgesic agent. Ketamine is a solid pharmacological agent and is phencyclidine derivative. Although termed as dissociative anesthetic agent, but it has not dissociated itself from the anesthesiologist’s shelf.
It has been recommended as a core drug (a minimum medical need for a basic health system) by World Health Organization (WHO) on the basis of clinical trials, research statistics, various case reports and also from opinions of experts. The current narrative review aims to highlight these aspects through a short journey from its pharmacological profile to its older and recent indications.