Obesity Kills: Can Genetics Help in the Targeting of Obesity Prevention?

Obesity is becoming a worldwide epidemic and is a major public-health-threatening problem in most countries in the world. A recent paper in The Lancet involving 19.2 million participants broke the news by forecasting that, if the current trends of weight gain continue, by 2025, the global obesity (BMI>30) prevalence will reach 18% among men and surpass 21% among women (39% for all); severe obesity will exceed 6% among men and 9% among women (BMI>35, 15% for all).


Obesity means an excess accumulation of body fat tissue and is caused by a combination of excessive food intake, a lack of physical activity, and genetic susceptibility.Severe and morbid obesity are associated with highly elevated risks of adverse health outcomes, i.e., metabolic diseases (type 2 diabetes), higher morbidity and mortality for a variety of diseases as well as higher overall mortality. It has been estimated that overweight decreases an individual’s life expectancy by eight years.


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