Role of Cav2.1 Channel Signaling in Glutamate-Related Brain Injury

Cerebral ischemia, seizures, traumatic brain injury. Neuroprotection has been studied worldwide in the context of brain injuries, including neurodegenerative diseases, cerebral ischemia, epilepsy and seizures, and traumatic brain injury (TBI). Cerebral ischemia is one of the most common causes of death in adults worldwide, resulting in necrosis and apoptosis in the brain that in turn leads to a high possibility of ischemic stroke-related disability . Epilepsy, characterized by multiple, unpredictable seizures, is a common neuronal disease in human populations regardless of age, sex, or race.

Glutamate-Related Brain Injury
Glutamate-Related Brain Injury

Approximately 1% of the population worldwide is known to have epilepsy, which often requires lifelong medication. TBI, which is typically due to falls or motor vehicle- or sports-related accidents, is a serious health issue regardless of age. Approximately 1.4 million patients visit emergency rooms in the USA each year due to TBI. The need for treatment of such brain injuries appears to be dramatically increasing. Therefore, in this paper, we review the role of the Cav2.1 channel in cerebral ischemia, seizures, and TBI.


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