Quantifiable Metrics for Predicting MSC Therapeutic Efficacy

Currently there are over 600 clinical trials listed at www. clinicaltrials.gov utilizing Mesenchymal Stromal Cells (MSCs) as an experimental cell-based therapy, making MSCs the most commonly employed cell type under investigation for treating human diseases. MSCs have gained widespread use in regenerative medicine due to their demonstrated potency in a broad range of experimental animal models of disease and their excellent safety profile in human clinical trials. However, while MSC-based therapies have clearly shown benefits in patients with ischemic and immune-related disorders, many trials completed to date have yielded suboptimal outcomes and several have failed to meet their primary endpoints of efficacy.

Predicting MSC Therapeutic Efficacy
Predicting MSC Therapeutic Efficacy

A challenge in the development of efficacious MSC-based therapies is the inability to consistently manufacture homogeneous populations of cells with known efficacy for a specific disease indication that yield predictable and reproducible patient outcomes. This difficulty stems from the fact that methods routinely used to isolate MSCs yield populations that exhibit significant heterogeneity in terms of morphologic features, growth rate, life span, differentiation potential, and potency in functional-based assays.


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s