Human bocavirus (HBov1 and HBov2) in Children with Acute Gastroenteritis from North India

Acute Gastroenteritis (AGE) is a major cause of morbidity and mortality in children worldwide. Several viruses are associated with gastroenteritis, including rotavirus, adenovirus, astrovirus and calicivirus etc. However, about 35-50% of non-bacterial acute Gastroenteritis is un-identifiable due to unrecognized etiologies. Parvovirus is known to cause gastroenteritis in numerous animal species including dogs, cats and hamsters. Several different species and genotypes of Parvovirus infect humans, including the well characterized Parvovirus B19, PARV4, PARV5 and recently identified bocavirus.

Human bocavirus
Human bocavirus

Human bocavirus (HBoV), a well-known parvovirus was identified a decade ago in respiratory samples as well as in stool samples. Since then its global presence has been reported in patients with or without gastroenteritis. The Human bocavirus (HBoV) genome consists of approximately 5.2 kb nucleotides in length and contains three open-reading frames (ORF) encoding two non-structural proteins (NS1 and NP1) and two capsid proteins (VP1 and VP2)


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