The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology

Mental diseases have become common in modern society, which seriously harm the human health. There are nearly 100 million people with mental diseases worldwide currently, onset mostly in young adults, it gradually becomes chronic, with high recurrence rate and disability rate. Without active treatment, patients may suffer from mental deterioration and personality changes, and difficult to adapt to social life. The etiology of mental diseases is complex, general theories and methods of mechanism and prevention guidance of mental diseases cannot fully explain the clinical hysteresis effects of anti-psychotic and anti-neuropathic drugs.

Melatonin on Mental Disorders
Melatonin on Mental Disorders

And current treatments for mental diseases are limited in their efficacy, because their therapeutic benefits can take several weeks before setting in and they are only effective in approximately one third of people. Individuals with treatment-resistant mental diseases often suffer greatly in the absence of an effective drug treatment. The current clinical application of drugs of mental diseases in play a role of treatment at the same time, also often occur as extrapyramidal side effects (EPS), increase the quality of body, electrocardiogram (ecg) changes (such as QTC extension), hyperglycemia, hyperlipidemia and other adverse reactions. Various types of drugs because of different structures, its mechanism is also different.

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