Frailty is an age-related syndrome that is highly correlated with functional decline and chronic disease, leading to loss of independence and increased mortality. There are multiple causes and contributors to frailty, which can be characterized by diminished strength, endurance, and reduced physiologic function. Theoretically, frailty has also been defined as a state of increased vulnerability due to aging-associated decline in reserve and function across multiple physiologic systems, leading to an inability to cope with chronic or acute stressors.
Although a number of biomarkers have been tested in relation to frailty, experts have agreed that no single biomarker by itself is adequate for the assessment of frailty. There are some indications that a combination of biomarkers may be more useful, however there has been no consensus on which combination would be best. Therefore for clinical purposes, laboratory testing for frailty is not indicated. For research purposes, however, there are some more common biomarkers that have been shown to be associated with physical frailty.