Regenerative Surgery in the Management of the Leg Ulcers

The leg ulcers are a difficult battle-field for the regenerative medicine, due to several and different factors suggested as responsible of “hard to heal” leg ulcers, including the role of biofilms produced by pathogenic bacteria, aging and exhaustion of the tissue reparative capacity. From a clinical point of view, the introduction of advanced devices and procedures such as compression therapy, have certainly improved results and increased rates of clinical outcome.

Leg Ulcers
Leg Ulcers

On the other hand, scientific studies have emphasized the role of both extracellular matrix (ECM) in the early stages of tissue repair and growth factors involved in the different phases of tissue reparation. Also the biomaterials clinical spreading, used to cover large areas of skin, has allowed to focus on the problems of large implantation of autologous skin grafts, consisting essentially of scarring and contraction of the skin resulting in functional impairment.

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