The Urgent Need of New Mood-Stabilizers: The Promising Results of Memantine

The main aim of pharmacological treatment for Bipolar Disorder (BD) patients is the prevention of manic/hypomanic and depressive episodes by the administration of mood stabilizer drugs.Unfortunately, after several decades of its serendipitous discovery, lithium remains the only drug with consolidated evidence of moodstabilizing effect. No important therapeutic innovations (i.e., a drug with major clinical benefit compared with existing drugs, according to the definition of Motola have been introduced in the last 60 years

New Mood-Stabilizers
New Mood-Stabilizers

Some anticonvulsant medications and atypical antipsychotics are currently approved or used off-label as lithium alternative mood stabilizers. Anticonvulsants have been shown to be of limited efficacy both as a monotherapy and in combination with lithium and the mood stabilizing effect of atypical antipsychotics has been severely questioned.


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