Effect of Hippophae Rhamnoides Leaf Extract against Dengue Virus Infection in U937 Cells

The use of herbal extracts either as alternative or complimentary medicine to the conventional chemotherapy is well documented in Ayurveda. Number of medicinal plants having significant immunomodulatory properties have been identified. There are well known and widely used plants possessing antiviral properties e.g., Mimosa scabrella and Leucaena leucocephala against Yellow fever virus and Dengue 1 virus, Olive leaf extract against HIV-1, Hippophae rhamnoides and Rhodiola are documented to have antiviral properties against Dengue virus. Several plants, approximately 50 different species have been reported to contain antiviral components such as terpenoids, coumarins, polyphenols, tannins, proteins, alkaloids, and biflavonoids which can inhibit HIV life cycle at different stages, Aristolochia indica Cassia occidentalis, Phyllanthus niruri Withania somnifera Tinospora cordifolia agsinst HIV, Rhus chinensis and Rhus javanica against HSV.

Dengue Virus Infection
Dengue Virus Infection

Seabuckthorn (Hippophae rhamnoides), Family- Elaeagnaceae, a traditional popular medicinal plant, also called a wonder plant, is used in various parts of the world. Medicinal properties of Seabuckthorn are documented by the name “Amlavetas” in the ancient Indian Medical Classic “Ayurveda” where it is described as a plant with various medicinal properties, briefly as a health protection plant in Himalaya.

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