Thiopeptide Antibiotics act on both Host and Microbe to Deliver Double Punch on Mycobacterial Infection

Infectious diseases, the second leading cause of death worldwide, exert a grave threat to the public health. This situation is aggravating due to the progressively emerging microbial resistance and the lack of new drugs into the clinic. Mycobacterial infection has had its notorious name engraved on the Georgia Guidestones. For instance, human tuberculosis, which is mainly caused by Mycobacterium tuberculosis, causes approximately more than 1.5 million deaths each year. The stinky devil shows no regret in escalating its influence and evolves multidrug-resistant tuberculosis levering up the costs of corresponding treatment. It brooks no delay to search for effective drugs against.

Thiopeptide Antibiotics
Thiopeptide Antibiotics

Natural products remain a major source for antibiotic discovery and drug development; however, the accessibility and efficiency for chemical synthesis of these compounds, as well as the associated investigation into their mechanisms of action, often get choked by challenges arising from the structural complexity.

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