Production of Sterilized Medium Chain Length Polyhydroxyalkanoates (Smcl- Pha) as a Biofilm to Tissue Engineering Application

Polyhydroxyalkanoates (PHAs) are a category of natural polyesters as energy reserves in several species of microorganisms. They are wholly biodegradable, biocompatible and piezoelectric biopolymers that have attracted much attention recently as the biomaterial of choice for medical applications. Polyhydroxyalkanoates can be considered as the natural biodegradable biomaterials used in different human clinical conditions. These biopolymers, due to their bioactive properties, they tend to have greater biological interaction with the cells, which allow them to have better performance in the biological system. Adequate investigations have now been suggest PHA biopolymers promise to have a significant role in tissue engineering and the development of novel living tissue products for therapeutic applications. These pledges of PHAs are due to it characteristics of biocompatible, support cell growth, guide and organize the cells, allow tissue in growth and, ultimately and degrade to non-toxic products.


Tissue engineering approaches employs scaffolds surface to be conducive to cell attachment and subsequent tissue growth. This scaffolding composed of natural materials is commonly used as scaffolds to interact with biological systems to accomplish desirable medical outcomes in modern healthcare, providing alternatives to overcome the limitations and restrictions imposed by the use of autograft and allograft tissues.


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