Incidence of Electrographic Seizures in Pharmacologically Paralyzed Patients

Critically ill patients sometimes require neuromuscular blockade for facilitation of ventilation, control of intracranial pressure or muscle spasms. These patients typically undergo continuous EEG monitoring (cEEG) during neuromuscular blockade to assess for seizure activity and to monitor the depth of sedation. However, cEEG is costly and resource-intensive.

Electrographic Seizures
Electrographic Seizures

In addition, heavy sedation is used to prevent discomfort, agitation and awareness during induced paralysis. These sedative medications often have strong anticonvulsant properties which would predict low incidence of seizures in this population. However, there is limited data about the frequency of seizures in critically ill patients undergoing neuromuscular blockade.

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