Acne vulgaris is chronic inflammatory skin disease; it’s one of the most common skin disorders. The presence of facial and shoulder lesions, pustules, pimples and sometime abscess accompanied by disease can produce a psychological burden on the patients. Combination of several factors such as hormonal changes, excessive production of sebum and accumulation of exfoliates; allow bacterial growth resulting in the inflammation of the skin. Acne affects mainly adolescents and young adults, with up to 90% of adolescents affected by acne at some stage. In addition, 5% of adults suffer from persistent or late onset acne. Regarding to the prevalence of acne, studies show that more than 20% of adolescents with acne seek help from medical professionals. Instead, individuals either do not treat their acne or self-treat with over the counter products.
Salicylic acid belongs to β-hydroxy acids Pka3 which is most widely used in common skin disease like acne, psoriasis, warts, corn and calluses. It used mainly for its keratolytic, bacteriostatic, fungicidal, and photoprotective properties by different concentrations vary from 0.5% to 60% in topical preparation.