Frontal-sub cortical syndrome: A disorder which may lead to dementia

The frontal-sub cortical syndrome is an extensive disorder that mostly affects cognition and mood. This dysfunction is usually related to prevalent factors among the elderly population in the form of strokes small vessel lesions and metabolic syndrome. Its epidemiology is not accurately known. However, around 22% of the United States population older than 70 years has some kind of mild cognitive impairment with no criteria for specific dementias. This is considered as a serious apprehension since the mortality for FSCS patients is higher than the mortality of other cognitive impaired patients such as Alzheimer’s disease.


The frontal lobe is a leading player for human superior functions. Restricted damage to certain parts of the frontal lobe, such as to prefrontal convexity, orbitofrontal, and medial frontal cortex, can cause specific and distinct syndromes. Nonetheless, the same pattern of syndromes can emerge from subcortical impairment, suggesting a well-defined circuitry connecting these otherwise autonomous portions of brain.

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