The following three discoveries, identification of master gene regulator targets, small molecules capable of altering gene expression, and availability of drug delivery by viral and non- viral carriers to organ, cell and mitochondrial-sites provide the potential for magic bullets for multiple human pathologies. Despite disease symptomatic differences, fundamental stresses and abnormal gene function are shared and subject to treatment by common drugs. The master gene regulators are identified by their conservation throughout evolution, since nature demands stress resistance for survival. The common stresses are oxidative, hunger, thirst, energy depletion, temperature, and infection. Tolerance strategies and drugs employed to treat the common stresses are candidates to treat HIV. Mimetics of tolerance, and stress resistance agents used to tolerate stress in different organisms are reservoirs for drug intervention applicable in HIV therapeutics.
The master regulator, telomerase, is identified by its phylogenetic conservation throughout evolution. Clues from studies of high resolution of telomerase structure, its subunits, and potential interactions reveal its ancient origin and remarkable similarities with retroviruses and HIV, and reveal drug target potentials for HIV therapy. The diversity of functions of telomerase in the nucleus, cytoplasm, nucleolus, and mitochondria, provide a myriad of interactions and potential for interaction sites with HIV amenable to regulation.