Magnesium (Mg2+) is the second most abundant intracellular cation and an essential ingredient in the body’s electrolyte and metabolic constitution. It serves as an essential co-factor in multitude enzymes reactions, especially those involved in energy metabolism, phosphate transfer, muscle contractility and neurochemical transmission. Magnesium sulfate (MgSO4) used for many years on an empirical basis for the control of convulsions in patients with pre-eclamptic toxemia.
It has been suggested that substances with calcium channelblocking effect and NMDA (N-Methyl-D-Aspartate) receptor antagonist may prevent pain and facilitate treatment of established pain states. Magnesium is a physiological calcium channel blocker agent and NMDA receptor antagonist that suppress induced adverse behavioral reactions and autotomy caused by nerve injuries in animals. To our knowledge there are no published papers on the use of magnesium sulfate for spinal anesthesia in donkeys.