Bacterial Biofilm: Its Composition, Formation and Role in Human Infections

Biofilms are group or micro-organisms in which microbes produced an extracellular polymeric substances (EPS) such as proteins (<1-2%) including enzymes), DNA (<1%), polysaccharides (1-2%) and RNA (<1%), and in addition to these components, water (up to 97%) is the major part of biofilm which is responsible for the flow of nutrients inside biofilm matrix. The architecture of biofilm consists of two main components i.e. water channel for nutrients transport and a region of densely packed cells having no prominent pores in it. The microbial cells with in biofilms are arranged in way with significant different physiology and physical properties. Bacterial biofilms are normally beyond the access of antibiotics and human immune system.

bacterial-biofilm
Bacterial Biofilm

Microorganisms that produce biofilm have enhanced potential to bear and neutralize antimicrobial agents and result in prolonged treatment. Biofilm forming bacteria switch on some genes that activate the expression of stress genes which in turn switch to resistant phenotypes due certain changes e.g. cell density, nutritional or temperature, cell density, pH and osmolarity. When the biofilm water channels are compared with system of circulations showed that biofilms are considered primitive multi-cellular organisms. Various components of biofilms are shown in Table1 signify the biofilm integrity and making it resistant against various environmental factors.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s