Paraneoplastic Neurological Syndrome

Paraneoplastic neurological syndrome (PNS) is defined as an effect of a cancer situated outside the nervous system, distant in time and space. The cancer has an influence on the nervous structure, neuromuscular junction and muscles via the secretion of different mediators, such as peptides, cytokines, hormones, and activating immunological processes. Nonsmall cell neuro-endocrine lung cancer is very rare (2-3% of all lung cancers). The authors present a complex case of PNS, among them chorea, as a first manifestation of this type of lung cancer.

Paraneoplastic Neurological Syndrome
Neurological Syndrome

The 64-year-old woman had a complex medical history: hypertension, lipid disorders, bronchial asthma and depressive syndrome. The case history lasted from January 2012 to July 2013. She complained of visual disturbances in the form of image “merging”, periodic double vision, and right hemihypoesthesia.


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