The incidence of hypoxemia is reportedly from 5% to 10% during one-lung ventilation (OLV). High tidal volume and airway pressure during OLV correlated with the development of acute ventilationinduced lung injury in patients undergoing lung resection. Inverse ratio ventilation (IRV) has been proposed for patients with adult respiratory distress syndrome to achieve adequate oxygenation, due to recruiting atelectatic alveoli, and it is reported that the optimal inspiratory to expiratory ratio (I:E) is 2:1 when using IRV.
This study was approved by the Hospital Ethics Committee of Jiaxing maternity and child health care hospital and registered in protocol registration system (registration number: ChiCTR-IOR-15006517). The informed consent was signed before enrollment by the patients. From May 2015 to December 2015, we identified 60 patients undergoing elective lung lobectomy with ASA grade II, age 34-61 years, body mass index (BMI) 21-29 kg/m2 and minute ventilation volume > 70 L/min to enroll in this study. We excluded the patients that had the history of severe cardiovascular disease, asthma, chronic obstructive pulmonary disease and pneumothorax.