Influenza virus belongs to the family Orthomyxoviridae with a genome makeup of seven or eight single-stranded, negative-sense RNA segments. Influenza A viruses are a major cause of acute respiratory infections, responsible for annual epidemics and irregular pandemics in humans worldwide. In the spring of 2009, novel swine-origin Influenza A virus was detected in Mexico. On June 11, 2009, the world health organization (WHO) declared a phase-6 alert, indicating first pandemic of the 21st century caused by Influenza A (H1N1) virus.
Antiviral agents confer significant prophylactic and therapeutic benefits during seasonal Influenza outbreaks and unexpected Influenza pandemics. The development and occurrence of antiviral drug resistance in human Influenza viruses has been extensively studied over the last decade. Initial analysis of Influenza A (H1N1) pdm 09 revealed that the virus was resistant to the Adamantanes class of drugs that inhibit the M2 ion channel.