Guillain Barre Syndrome (GBS) is an autoimmune inflammatory neuropathy. It affects all age group of both sexes and can lead to morbidity if untreated. It is usually preceded by an infection and has a fast progression. Matrix metalloproteinase (MMP’s) are the biggest family of extra cellular matrix degrading enzymes. MMP’s participate in physiological processes like inflammation, immunity, neurite growth, through pro-neurotropic factors and chemokines/cytokines.
In the Central Nervous System (CNS), their role in neurogenesis, axonal guidance and learning and memory has been delineated. A central role of MMP’s and cytokines in mediating inflammatory demyelinating diseases of Central Nervous System (CNS) and Peripheral Nervous System (PNS) has been indicated, with GBS being an example of the latter.